Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 27, Pages 11014-11018Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1200430109
Keywords
computational neuroscience; branching; dendrite; morphology; minimum spanning tree
Categories
Funding
- Alexander von Humboldt Foundation
- Max Planck Society
- Gatsby Charitable Foundation
- European Research Council
- Wellcome Trust
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The wide diversity of dendritic trees is one of the most striking features of neural circuits. Here we develop a general quantitative theory relating the total length of dendritic wiring to the number of branch points and synapses. We show that optimal wiring predicts a 2/3 power law between these measures. We demonstrate that the theory is consistent with data from a wide variety of neurons across many different species and helps define the computational compartments in dendritic trees. Our results imply fundamentally distinct design principles for dendritic arbors compared with vascular, bronchial, and botanical trees.
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