Journal
EPIGENOMICS
Volume 7, Issue 7, Pages 1111-1122Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi.15.72
Keywords
cord blood; DNA methylation; epigenetics; gestational diabetes; placenta
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Funding
- ECOGENE- 21 Clinical Research Center
- Canadian Institutes of Health Research (CIHR)
- Fonds de Recherche du Quebec en Sante (FRQS)
- Diabete Quebec
- American Heart Association (AHA)
- American Diabetes Association (ADA)
- Fonds de la Recherche en Sante du Quebec (FRQS)
- Canadian Diabetes Association (CDA)
- Faculte de Medecine et des Sciences de la Sante de l'Universite de Sherbrooke
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Aim: To assess the associations between gestational diabetes mellitus (GDM) and DNA methylation levels at genes related to energy metabolism. Patients & methods: Ten loci were selected from our recent epigenome-wide association study on GDM. DNA methylation levels were quantified by bisulfite pyrosequencing in 80 placenta and cord blood samples (20 exposed to GDM) from an independent birth cohort (Gen3G). Results: We did not replicate association between DNA methylation and GDM. However, in normoglycemic women, glucose levels were associated with DNA methylation changes at LRP1B and BRD2 and at CACNA1D and LRP1B gene loci in placenta and cord blood, respectively. Conclusion: These results suggest that maternal glucose levels, within the normal range, are associated with DNA methylation changes at genes related to energy metabolism and previously associated with GDM. Maternal glycemia might thus be involved in fetal metabolic programming.
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