Journal
EPIGENOMICS
Volume 7, Issue 5, Pages 733-744Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi.15.34
Keywords
epigenetic biomarkers; nomogram; oncological outcomes; predictive model; upper tract urothelial carcinoma
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Funding
- Collaborative Research Foundation of Peking University Health Science Center
- National Taiwan University, College of Medicine [BMU20120318]
- Natural Science Foundation of Beijing [7122183, 7152146]
- Natural Science Foundation of China [81172419, 81372746]
- Clinical Features Research of Capital [Z151100004015173]
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Aim: We conducted this study to identify gene promoter methylation status and clinical predictors for upper tract urothelial carcinoma (UTUC) patients. Materials & methods: Using methylation-sensitive PCR, we examined ten genes promoter methylation status in 687 UTUC patients. Results: A methylated promoter of three genes to predict higher tumor stage (T3 and T4), five genes to predict higher tumor grade (G3) and one gene to predict pN+ were certified in this study. Nine factors were significantly associated with poor cancer-specific survival. Six factors were considered as predictors to develop bladder recurrence after surgery. Conclusion: Methylation occurs commonly in UTUCs, may affect carcinogenic mechanisms, and is a well predictive factor for cancer-specific survival and bladder recurrence in UTUCs.
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