Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 50, Pages 20298-20302Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1109545108
Keywords
ecological genomics; ecotoxicology; microarray; RNA-seq; toxicogenomics
Categories
Funding
- National Science Foundation [DEB-1048206, DEB-1120512, EF-0723771, DEB-1048241]
- National Institutes of Health [R15-ES016905-01]
- Gulf of Mexico Research Initiative
- Direct For Biological Sciences
- Division Of Environmental Biology [1048206] Funding Source: National Science Foundation
- Division Of Environmental Biology
- Direct For Biological Sciences [1265282, 1048241, 1120333] Funding Source: National Science Foundation
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The biological consequences of the Deepwater Horizon oil spill are unknown, especially for resident organisms. Here, we report results from a field study tracking the effects of contaminating oil across space and time in resident killifish during the first 4 mo of the spill event. Remote sensing and analytical chemistry identified exposures, which were linked to effects in fish characterized by genome expression and associated gill immunohisto-chemistry, despite very low concentrations of hydrocarbons remaining in water and tissues. Divergence in genome expression coincides with contaminating oil and is consistent with genome responses that are predictive of exposure to hydrocarbon-like chemicals and indicative of physiological and reproductive impairment. Oil-contaminated waters are also associated with aberrant protein expression in gill tissues of larval and adult fish. These data suggest that heavily weathered crude oil from the spill imparts significant biological impacts in sensitive Louisiana marshes, some of which remain for over 2 mo following initial exposures.
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