Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 108, Issue 39, Pages 16463-16468Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1113726108
Keywords
nucleotide-binding domain and leucine-rich repeat-containing protein receptors; plant immune system; effector-triggered immunity; microbial-associated molecular pattern-triggered immunity
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Funding
- National Institutes of Health [RO1GM066025, R01GM057171]
- National Science Foundation [IOS-0929410]
- Human Frontier Science Program [LT00905/2006-L]
- National Natural Science Foundation of China [30671180]
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Plants and animals deploy intracellular immune receptors that perceive specific pathogen effector proteins and microbial products delivered into the host cell. We demonstrate that the ADR1 family of Arabidopsis nucleotide-binding leucine-rich repeat (NB-LRR) receptors regulates accumulation of the defense hormone salicylic acid during three different types of immune response: (i) ADRs are required as helper NB-LRRs to transduce signals downstream of specific NB-LRR receptor activation during effector-triggered immunity; (ii) ADRs are required for basal defense against virulent pathogens; and (iii) ADRs regulate microbial-associated molecular pattern-dependent salicylic acid accumulation induced by infection with a disarmed pathogen. Remarkably, these functions do not require an intact P-loop motif for at least one ADR1 family member. Our results suggest that some NB-LRR proteins can serve additional functions beyond canonical, P-loop-dependent activation by specific virulence effectors, extending analogies between intracellular innate immune receptor function from plants and animals.
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