Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 108, Issue 16, Pages 6579-6584Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1103904108
Keywords
paracrine FGF10 signaling; tyrosine kinase; tissue regeneration
Categories
Funding
- Army Medical Research and Material Command Grant [W81XWH-08-1-0329]
- Prostate Cancer Foundation (PCF)
- National Institutes of Health/National Institute of Child Health and Human Development [5 K12 HD001400]
- UCLA Jonsson Comprehensive Cancer Center Foundation
- Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research
- UCLA [T32 CA009056]
- [RO1CA41072]
- [RO1Al65495]
- [Al68150]
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Src family kinases (SFKs) are pleiotropic activators that are responsible for integrating signal transduction for multiple receptors that regulate cellular proliferation, invasion, and metastasis in a variety of human cancers. Independent groups have identified increased expression of individual SFK members during prostate cancer progression, raising the question of whether SFKs display functional equivalence. Here, we show that Src kinase, followed by Fyn kinase and then Lyn kinase, exhibit ranked tumorigenic potential during both paracrine-induced and cell-autonomous-initiated prostate cancer. This quantitative variation in transformation potential appears to be regulated in part by posttranslational palmitoylation. Our data indicate that development of inhibitors against specific SFK members could provide unique targeted therapeutic strategies.
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