4.8 Article

Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation

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NATL ACAD SCIENCES
DOI: 10.1073/pnas.1101503108

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Funding

  1. Howard Hughes Medical Institute
  2. National Institutes of Health [R01 GM29169, P01 GM064692, R01 GM079238]

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mRNA-tRNA translocation is a central and highly regulated process during translational elongation. Along with the mRNA, tRNA moves through the ribosome in a stepwise fashion. Using cryoelectron microscopy on ribosomes with a P-loop mutation, we have identified novel structural intermediates likely to exist transiently during translocation. Our observations suggest a mechanism by which the rate of translocation can be regulated.

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