Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 108, Issue 12, Pages 4817-4821Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1101503108
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Funding
- Howard Hughes Medical Institute
- National Institutes of Health [R01 GM29169, P01 GM064692, R01 GM079238]
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mRNA-tRNA translocation is a central and highly regulated process during translational elongation. Along with the mRNA, tRNA moves through the ribosome in a stepwise fashion. Using cryoelectron microscopy on ribosomes with a P-loop mutation, we have identified novel structural intermediates likely to exist transiently during translocation. Our observations suggest a mechanism by which the rate of translocation can be regulated.
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