Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 108, Issue 20, Pages 8345-8350Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1103894108
Keywords
sleeping sickness; Nagana; high through-put sequencing; noncoding RNAs; gene regulation
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Funding
- National Science Foundation of China [31071995]
- National Basic Research program (973 program) [2011CB811300]
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Pseudogenes have been shown to acquire unique regulatory roles from more and more organisms. We report the observation of a cluster of siRNAs derived from pseudogenes of African Trypanosoma brucei using high through-put analysis. We show that these pseudogene-derived siRNAs suppress gene expression through RNA interference. The discovery that siRNAs may originate from pseudogenes and regulate gene expression in a unicellular eukaryote provides insights into the functional roles of pseudogenes and into the origin of noncoding small RNAs.
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