Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 108, Issue 17, Pages 6893-6898Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1010894108
Keywords
Zea mays; Setosphaeria turcica; Exserohilum turcicum; quantitative trait loci mapping
Categories
Funding
- Generation Challenge Program
- McKnight Foundation
- Cornell University
- US National Science Foundation [DBI-0820619, 0321467, 0703908, 0638566]
- US Department of Agriculture-Agricultural Research Service
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0638566, 0703908, 0321467] Funding Source: National Science Foundation
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Quantitative resistance to plant pathogens, controlled by multiple loci of small effect, is important for food production, food security, and food safety but is poorly understood. To gain insights into the genetic architecture of quantitative resistance in maize, we evaluated a 5,000-inbred-line nested association mapping population for resistance to northern leaf blight, a maize disease of global economic importance. Twenty-nine quantitative trait loci were identified, and most had multiple alleles. The large variation in resistance phenotypes could be attributed to the accumulation of numerous loci of small additive effects. Genome-wide nested association mapping, using 1.6 million SNPs, identified multiple candidate genes related to plant defense, including receptor-like kinase genes similar to those involved in basal defense. These results are consistent with the hypothesis that quantitative disease resistance in plants is conditioned by a range of mechanisms and could have considerable mechanistic overlap with basal resistance.
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