Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 6, Issue 11, Pages 1099-1104Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.5b00258
Keywords
Drug development; ionic liquids; active pharmaceutical ingredients; salicylic acid; API-IL; cytotoxicity
Categories
Funding
- Russian Foundation for Basic Research [14-03-31478]
- Russian Federation [MK-5053.2015.3]
- Russian Science Foundation (RSF) [14-50-00126]
Ask authors/readers for more resources
Three different types of drug delivery platforms based on imidazolium ionic liquids (ILs) were synthesized in high preparative yields, namely, the models involving (i) ionic binding of drug and IL; (ii) covalent binding of drug and IL; and (iii) dual binding using both ionic and covalent approaches. Seven ionic liquids containing salicylic acid (SAILs) in the cation or/and in the anion were prepared, and their cytotoxicity toward the human cell lines CaCo-2 (colorectal adenocarcinoma) and 3215 LS (normal fibroblasts) was evaluated. Cytotoxicity of SA-ILs was significantly higher than that of conventional imidazolium-based ILs and was comparable to the pure salicylic acid. It is important to note that the obtained SA-ILs dissolved in water more readily than salicylic acid, suggesting benefits of possible usage of traditional nonsoluble active pharmaceutical ingredients in an ionic liquid form.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available