Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 6, Issue 7, Pages 722-725Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.5b00157
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The principles of molecular property optimization in drug design have been understood for decades, yet much drug discovery activity today is conducted at the periphery of historical druglike property space. Lead optimization trajectories aimed at reducing physicochemical risk, assisted by ligand efficiency metrics, could help to reduce clinical attrition rates.
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