Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 108, Issue 35, Pages E607-E616Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1103546108
Keywords
antidromic action potentials; CA1 pyramidal cells; interneurons; ripples
Categories
Funding
- Bundesministerium fur Bildung und Forschung (BMBF) (Bernstein Centre for Computational Neuroscience Heidelberg-Mannheim)
- Deutsche Forschungsgemeinschaft [SFB 636, SFB 618, SFB 665, EXC 257]
- BMBF (Bernstein Centre for Computational Neuroscience Berlin)
- Hertie Foundation
- National Institutes of Health/National Institute of Neurological Disorders and Stroke [NS44138, N5062955]
- IBM Corp.
- Alexander von Humboldt Stiftung
Ask authors/readers for more resources
Neurons form transiently stable assemblies that may underlie cognitive functions, including memory formation. In most brain regions, coherent activity is organized by network oscillations that involve sparse firing within a well-defined minority of cells. Despite extensive work on the underlying cellular mechanisms, a fundamental question remains unsolved: how are participating neurons distinguished from the majority of nonparticipators? We used physiological and modeling techniques to analyze neuronal activity in mouse hippocampal slices during spontaneously occurring high-frequency network oscillations. Network-entrained action potentials were exclusively observed in a defined subset of pyramidal cells, yielding a strict distinction between participating and nonparticipating neurons. These spikes had unique properties, because they were generated in the axon without prior depolarization of the soma. GABA(A) receptors had a dual role in pyramidal cell recruitment. First, the sparse occurrence of entrained spikes was accomplished by intense perisomatic inhibition. Second, antidromic spike generation was facilitated by tonic effects of GABA in remote axonal compartments. Ectopic spike generation together with strong somatodendritic inhibition may provide a cellular mechanism for the definition of oscillating assemblies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available