Journal
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
Volume 7, Issue 2, Pages 73-90Publisher
WILEY
DOI: 10.1002/wsbm.1290
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Funding
- British Heart Foundation [FS/12/82/29736] Funding Source: researchfish
- Medical Research Council [G9521010, MR/K006584/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10113] Funding Source: researchfish
- MRC [G9521010] Funding Source: UKRI
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Hypertension is a major risk factor for global mortality. Recent genome-wide association studies (GWAS) have led to successful identification of many genetic loci influencing blood pressure, although these studies account for less than 5% of heritability. While genetic discovery efforts continue, it is timely to pause and reflect on what information has been gained to date from reported loci. Knowledge from GWAS findings inform our understanding of the pathways and pleiotropy underpinning hypertension and aid in the identification of potential druggable targets. By reviewing blood pressure loci we aim to determine how much potential the current observations have for future clinical utility. (C) 2015 Wiley Periodicals, Inc.
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