4.8 Article

Gold nanorods 3D-supercrystals as surface enhanced Raman scattering spectroscopy substrates for the rapid detection of scrambled prions

Publisher

NATL ACAD SCIENCES
DOI: 10.1073/pnas.1016530108

Keywords

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Funding

  1. Spanish Ministerio de Ciencia e Innovacion
  2. Spanish Ministerio de Ciencia e Innovacion [MAT2010-15374, MAT2008-05755]
  3. Xunta de Galicia [PGIDIT09TMT011314PR, 08TMT008314PR]
  4. National Science Foundation (NSF) [R8112-G1, ECS-0601345, 0932823]
  5. National Institutes of Health [1R21CA121841, 5R01EB007350]
  6. Defense Advanced Research Planning Agency [W31P4Q-08-C-0426]
  7. Robert A. Welch Foundation [C-1703]
  8. NSF [DMR-0547399]
  9. Alliance for Nanohealth [W8XWH-07-2-0101]

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Highly organized supercrystals of Au nanorods with plasmonic antennae enhancement of electrical field have made possible fast direct detection of prions in complex biological media such as serum and blood. The nearly perfect three-dimensional organization of nanorods render these systems excellent surface enhanced Raman scattering spectroscopy substrates with uniform electric field enhancement, leading to reproducibly high enhancement factor in the desirable spectral range.

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