Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 22, Pages 10238-10243Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0913110107
Keywords
cortex; electrophysiology; local field potential; functional connectivity; monkey
Categories
Funding
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- National Eye Institute
- Wellcome Trust
- NATIONAL INSTITUTE OF MENTAL HEALTH [ZIAMH002896, ZICMH002899, ZIAMH002838] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [ZIANS003027] Funding Source: NIH RePORTER
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Functional MRI (fMRI) has uncovered widespread hemodynamic. uctuations in the brain during rest. Recent electroencephalographic work in humans and microelectrode recordings in anesthetized monkeys have shown this activity to be correlated with slow changes in neural activity. Here we report that the spontaneous. uctuations in the local. eld potential (LFP) measured from a single cortical site in monkeys at rest exhibit widespread, positive correlations with fMRI signals over nearly the entire cerebral cortex. This correlation was especially consistent in a band of upper gamma- range frequencies (40-80 Hz), for which the hemodynamic signal lagged the neural signal by 6-8 s. A strong, positive correlation was also observed in a band of lower frequencies (2-15 Hz), albeit with a lag closer to zero. The global pattern of correlation with spontaneous fMRI. uctuations was similar whether the LFP signal was measured in occipital, parietal, or frontal electrodes. This coupling was, however, dependent on the monkey's behavioral state, being stronger and anticipatory when the animals' eyes were closed. These results indicate that the often discarded global component of fMRI. uctuations measured during the resting state is tightly coupled with underlying neural activity.
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