Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 13, Pages 5919-5924Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1002006107
Keywords
Foxp3; microarray
Categories
Funding
- Juvenile Diabetes Research Foundation [4-2007-1057]
- National Institutes of Health [7R01AI51530, R37 AI053102]
- Joslin Diabetes Center's National Institute of Diabetes and Digestive
- Digestive and Kidney Diseases
- German Research Foundation [FE 801/1-1]
- Charles A. King Trust Postdoctoral Fellowship
- Canadian Institutes of Health Research
- Canadian Diabetes Association
Ask authors/readers for more resources
Regulatory T (Treg) cells that express the Foxp3 transcription factor are essential for lymphoid homeostasis and immune tolerance to self. Other nonimmunological functions of Treg cells, such as controlling metabolic function in adipose tissue, are also emerging. Treg cells originate primarily in the thymus, but can also be elicited from conventional T cells by in vivo exposure to low-dose antigen or homeostatic expansion or by activation in the presence of TGF beta in vitro. Treg cells are characterized by a distinct transcriptional signature controlled in part, but not solely, by Foxp3. For a better perspective on transcriptional control in Treg cells, we compared gene expression profiles of a broadpanel of Treg cells from various origins or anatomical locations. Treg cells generated by different means form different subphenotypes and were identifiable by particular combinations of transcripts, none of which fully encompassed the entire Treg signature. Molecules involved in Treg cell effector function, chemokine receptors, and the transcription factors that control them were differentially represented in these subphenotypes. Treg cells from the gut proved dissimilar to cells elicited by exposure to TGF beta in vitro, but instead they resembled a CD103(+)Klrg1(+) subphenotype preferentially generated in response to lymphopenia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available