Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 19, Pages 8782-8787Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0912176107
Keywords
osteoporosis; osteoclast; osteoblast
Categories
Funding
- National Institutes of Health [AG23176, DK70526, DK80459]
- American Federation for Aging Research
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We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the. ne vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.
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