Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 22, Pages 10160-10165Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0913745107
Keywords
killer cell immunoglobulin-like receptors; MHC class I
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Funding
- Medical Research Council, United Kingdom
- Wellcome Trust, United Kingdom
- Cancer Research UK
- MRC [G0500563] Funding Source: UKRI
- Medical Research Council [G0500563] Funding Source: researchfish
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Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides promote clustering of KIR at the interface of effector and target cells, but do not result in inhibition of NK cells. Our data show that, as for T cells, small changes in the peptide content of MHC class I can regulate NK cell activity.
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