Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 8, Pages 3829-3833Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0909710107
Keywords
intracranial recording; EEG; dimension of activation; thalamus; wake-to-sleep transition
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Thalamic and cortical activities are assumed to be time-locked throughout all vigilance states. Using simultaneous intracortical and intrathalamic recordings, we demonstrate here that the thalamic deactivation occurring at sleep onset most often precedes that of the cortex by several minutes, whereas reactivation of both structures during awakening is synchronized. Delays between thalamus and cortex deactivations can vary from one subject to another when a similar cortical region is considered. In addition, heterogeneity in activity levels throughout the cortical mantle is larger than previously thought during the descent into sleep. Thus, asynchronous thalamocortical deactivation while falling asleep probably explains the production of hypnagogic hallucinations by a still-activated cortex and the common self-over estimation of the time needed to fall asleep.
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