Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 5, Pages 2066-2071Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0910213107
Keywords
autonomic nervous system; epibranchial placode; neural circuit; Phox2b; neural crest
Categories
Funding
- Agence Nationale de la Recherche
- Fondation pour la Recherche Medicale
- Centre National de la Recherche Scientifique
- Medical Research Council [MC_U117570528] Funding Source: researchfish
- MRC [MC_U117570528] Funding Source: UKRI
Ask authors/readers for more resources
The wiring of the nervous system arises from extensive directional migration of neuronal cell bodies and growth of processes that, somehow, end up forming functional circuits. Thus far, this feat of biological engineering appears to rely on sequences of pathfinding decisions upon local cues, each with little relationship to the anatomical and physiological outcome. Here, we uncover a straightforward cellular mechanism for circuit building whereby a neuronal type directs the development of its future partners. We show that visceral afferents of the head (that innervate taste buds) provide a scaffold for the establishment of visceral efferents (that innervate salivatory glands and blood vessels). In embryological terms, sensory neurons derived from an epibranchial placode-that we show to develop largely independently from the neural crest-guide the directional outgrowth of hindbrain visceral motoneurons and control the formation of neural crest-derived parasympathetic ganglia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available