Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 108, Issue 1, Pages 61-66Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1017012108
Keywords
antiviral; biocide; virucidal coating
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Funding
- U.S. Army through the Institute of Soldier Nanotechnologies at the Massachusetts Institute of Technology [DAAD-19-02-D0002]
- Army Research Office
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N,N-Dodecyl, methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including pathogenic human and avian, both wild-type and drug-resistant, strains) irreversibly adhere to it, followed by structural damage and inactivation; subsequently, viral RNA is released into solution, while proteins remain adsorbed.
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