Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 50, Pages 21773-21777Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1010079108
Keywords
brain lesions; decision making; loss aversion; risk taking
Categories
Funding
- Korean government [MEST 2009-008145]
- Ministry of Education, Science and Technology [2009K001284]
- Republic of Korea
- Seoul Broadcasting System Foundation
- National Institutes of Health [MH64457]
- James McKeen Cattell Sabbatical Award
- National Research Foundation of Korea [2009-0081145, 22-2009-00-033-00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In a natural environment, foragers constantly face the risk of encountering predators. Fear is a defensive mechanism evolved to protect animals from danger by balancing the animals' needs for primary resources with the risk of predation, and the amygdala is implicated in mediating fear responses. However, the functions of fear and amygdala in foraging behavior are not well characterized because of the technical difficulty in quantifying prey-predator interaction with real (unpredictable) predators. Thus, the present study investigated the rat's foraging behavior in a seminaturalistic environment when confronted with a predator-like robot programmed to surge toward the animal seeking food. Rats initially fled into the nest and froze (demonstrating fear) and then cautiously approached and seized the food as a function of decreasing nest-food and increasing food-robot distances. The likelihood of procuring food increased and decreased via lesioning/inactivating and disinhibiting the amygdala, respectively. These results indicate that the amygdala bidirectionally regulates risk behavior in rats foraging in a dynamic fear environment.
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