Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 27, Pages 12192-12197Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1005443107
Keywords
immunoglobulin; immunological memory
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology in Japan
- Japan Science and Technology Agency, Core Research of Evolutional and Technology
- Grants-in-Aid for Scientific Research [21229007] Funding Source: KAKEN
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It has long been presumed that after leaving the germinal centers (GCs), memory B cells colonize the marginal zone or join the recirculating pool. Here we demonstrate the preferential localization of nitrophenol-chicken gamma-globulin-induced CD38(+)IgG1(+) memory B cells adjacent to contracted GCs in the spleen. The memory B cells in this region proliferated after secondary immunization, a response that was abolished by depletion of CD4(+) T cells. We also found that these IgG1(+) memory B cells could present antigen on their surface, and that this activity was required for their activation. These results implicate this peri-GC region as an important site for survival and reactivation of memory B cells.
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