Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 8, Pages 3693-3697Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1000386107
Keywords
hyperpolarized gas MRI; superparamagnetic iron oxide nanoparticles; luteinizing hormone-releasing hormone
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Funding
- National Institutes of Health [R01 EB02122, P41 RR005959]
- National Cancer Institute [U24 CA092656]
- Duke Comprehensive Cancer Center
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Early and specific detection of metastatic cancer cells in the lung (the most common organ targeted by metastases) could significantly improve cancer treatment outcomes. However, the most widespread lung imaging methods use ionizing radiation and have low sensitivity and/or low specificity for cancer cells. Here we address this problem with an imaging method to detect submillimeter-sized metastases with molecular specificity. Cancer cells are targeted by iron oxide nanoparticles functionalized with cancer-binding ligands, then imaged by high-resolution hyperpolarized He-3 MRI. We demonstrate in vivo detection of pulmonary micrometastates in mice injected with breast adenocarcinoma cells. The method not only holds promise for cancer imaging but more generally suggests a fundamentally unique approach to molecular imaging in the lungs.
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