Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 17, Pages 8029-8034Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0912311107
Keywords
non-RD kinase; pathogen-associated molecular pattern; pattern recognition receptor; ATPase; rice
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Funding
- National Institutes of Health [GM055962]
- US Department of Agriculture (USDA) Cooperative State Research, Education, and Extension Service (CSREES)-National Research Initiative-Applied Plant Genomics Program [2004-35317-14867]
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Cell-surface pattern recognition receptors (PRRs) are key components of the innate immune response in animals and plants. These receptors typically carry or associate with non-RD kinases to control early events of innate immunity signaling. Despite their importance, the mode of regulation of PRRs is largely unknown. Here we show that the rice PRR, XA21, interacts with XA21 binding protein 24 (XB24), a previously undescribed ATPase. XB24 promotes autophosphorylation of XA21 through its ATPase activity. Rice lines silenced for Xb24 display enhanced XA21-mediated immunity, whereas rice lines overexpressing XB24 are compromised for immunity. XB24 ATPase enzyme activity is required for XB24 function. XA21 is degraded in the presence of the pathogen-associated molecular pattern Ax21 when XB24 is overexpressed. These results demonstrate a function for this large class of broadly conserved ATPases in PRR-mediated immunity.
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