Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 17, Pages 7957-7962Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0912478107
Keywords
assembly sequence; cell assembly; phase precession; phase coding; ventral hippocampus
Categories
Funding
- National Institutes of Health [NS34994, MH54671]
- National Science Foundation [SBE 0542013]
- James S. McDonnell Foundation
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Driven either by external landmarks or by internal dynamics, hippocampal neurons form sequences of cell assemblies. The coordinated firing of these active cells is organized by the prominent theta oscillations in the local field potential (LFP): place cells discharge at progressively earlier theta phases as the rat crosses the respective place field (phase precession). The faster oscillation frequency of active neurons and the slower theta LFP, underlying phase precession, creates a paradox. How can faster oscillating neurons comprise a slower population oscillation, as reflected by the LFP? We built a mathematical model that allowed us to calculate the population activity analytically from experimentally derived parameters of the single neuron oscillation frequency, firing field size (duration), and the relationship between within-theta delays of place cell pairs and their distance representations (compression). The appropriate combination of these parameters generated a constant frequency population rhythm along the septo-temporal axis of the hippocampus, while allowing individual neurons to vary their oscillation frequency and field size. Our results suggest that the faster-than-theta oscillations of pyramidal cells are inherent and that phase precession is a result of the coordinated activity of temporally shifted cell assemblies, relative to the population activity, reflected by the LFP.
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