Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 8, Pages 2820-2824Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1010559107
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Funding
- Novartis Pharmaceuticals, Inc.
- National Cancer Institute [CA89393]
- Department of Defense [W81XWH-07-1-0294]
- Avon Foundation
- Breast Cancer Research Foundation
- Susan G. Komen Foundation
- Terri Brodeur Breast Cancer Foundation
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Transcriptome profiling studies suggest that a large fraction of the genome is transcribed and many transcripts function independent of their protein coding potential. The relevance of noncoding RNAs (ncRNAs) in normal physiological processes and in tumorigenesis is increasingly recognized. Here, we describe consistent and significant differences in the distribution of sense and antisense transcripts between normal and neoplastic breast tissues. Many of the differentially expressed antisense transcripts likely represent long ncRNAs. A subset of genes that mainly generate antisense transcripts in normal but not cancer cells is involved in essential metabolic processes. These findings suggest fundamental differences in global RNA regulation between normal and cancer cells that might play a role in tumorigenesis.
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