Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 107, Issue 10, Pages 4705-4709Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0910397107
Keywords
lesion patients; voxel-based lesion-symptom mapping; Wechsler Adult Intelligence Scale; white matter
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Funding
- Akademie der Naturforscher Leopoldina [9901/8-140]
- National Institutes of Health [P01NS19632, R01DA022549, R01MH080721]
- Simons Foundation
- Japanese Ministry of Education, Culture, Sports, and Technology
- Ministry of Education and Culture, Spain [SEJ-2006-07890]
- Ministry of Science and Innovation, Spain [PR2008-0038]
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General intelligence (g) captures the performance variance shared across cognitive tasks and correlates with real-world success. Yet it remains debated whether g reflects the combined performance of brain systems involved in these tasks or draws on specialized systems mediating their interactions. Here we investigated the neural substrates of g in 241 patients with focal brain damage using voxel-based lesion-symptom mapping. A hierarchical factor analysis across multiple cognitive tasks was used to derive a robust measure of g. Statistically significant associations were found between g and damage to a remarkably circumscribed albeit distributed network in frontal and parietal cortex, critically including white matter association tracts and frontopolar cortex. We suggest that general intelligence draws on connections between regions that integrate verbal, visuospatial, working memory, and executive processes.
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