Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 106, Issue 23, Pages 9362-9367Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0903103106
Keywords
catalog; evolution; GWAS; polymorphism; disorders
Categories
Funding
- National Human Genome Research Institute
- National Library of Medicine
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We have developed an online catalog of SNP-trait associations from published genome-wide association studies for use in investigating genomic characteristics of trait/disease-associated SNPs (TASs). Reported TASs were common [ median risk allele frequency 36%, interquartile range (IQR) 21% - 53%] and were associated with modest effect sizes [ median odds ratio ( OR) 1.33, IQR 1.20 - 1.61]. Among 20 genomic annotation sets, reported TASs were significantly overrepresented only in nonsynonymous sites [ OR = 3.9 (2.2 - 7.0), p = 3.5 x 10(-7)] and 5kb-promoter regions [ OR = 2.3 (1.5 - 3.6), p = 3 x 10(-4)] compared to SNPs randomly selected from genotyping arrays. Although 88% of TASs were intronic (45%) or intergenic (43%), TASs were not overrepresented in introns and were significantly depleted in intergenic regions [ OR = 0.44 (0.34 = 0.58), p = 2.0 x 10(-9)]. Only slightly more TASs than expected by chance were predicted to be in regions under positive selection [OR = 1.3 (0.8 x 2.1), p = 0.2]. This new online resource, together with bioinformatic predictions of the underlying functionality at trait/disease-associated loci, is well-suited to guide future investigations of the role of common variants in complex disease etiology.
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