Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 106, Issue 27, Pages 11049-11054Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0901801106
Keywords
coactivators; protein complex
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Funding
- Russian Academy of Sciences and a Scientific School [2994.2008.4]
- Russian Foundation for Basic Research [07-04-00723, 08-04-91976, 08-04-12216]
- University of Oslo, Centre for Medical Studies in Russia
- President of the Russian Federation [MK-4106.2007.4]
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Transcription activation by RNA polymerase II is a complicated process driven by combined, precisely coordinated action of a wide array of coactivator complexes, which carry out chromatin-directed activities and nucleate the assembly of the preinitiation complex on the promoter. Using various techniques, we have shown the existence of a stable coactivator supercomplex consisting of the chromatin-remodeling factor Brahma (SWI/SNF) and the transcription initiation factor TFIID, named BTFly (Brahma and TFIID in one assembly). The coupling of Brahma and TFIID is mediated by the SAYP factor, whose evolutionarily conserved activation domain SAY can directly bind to both BAP170 subunit of Brahma and TAF5 subunit of TFIID. The integrity of BTFly is crucial for its ability to activate transcription. BTFly is distributed genome-wide and appears to be a means of effective transcription activation.
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