Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 106, Issue 14, Pages 5497-5502Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0901592106
Keywords
acid-sensitive; biocompatible; encapsulation; polymer; vaccine
Categories
Funding
- National Institutes of Health National Institute of Biomedical Imaging and Bioengineering [RO1 EB005824]
- National Institutes of Health Program of Excellence in Nanotechnology [1 U01 HL080729-01]
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Materials that combine facile synthesis, simple tuning of degradation rate, processability, and biocompatibility are in high demand for use in biomedical applications. We report on acetalated dextran, a biocompatible material that can be formed into microparticles with degradation rates that are tunable over 2 orders of magnitude depending on the degree and type of acetal modification. Varying the degradation rate produces particles that perform better than poly(lactic-co-glycolic acid) and iron oxide, two commonly studied materials used for particulate immunotherapy, in major histocompatibility complex class I (MHC I) and MHC II presentation assays. Modulating the material properties leads to antigen presentation on MHC I via pathways that are dependent or independent of the transporter associated with antigen processing. To the best of our knowledge, this is the only example of a material that can be tuned to operate on different immunological pathways while maximizing immunological presentation.
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