Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 106, Issue 38, Pages 16257-16262Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0902150106
Keywords
BRDT; chromatin; FRET; HDAC inhibitor
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Funding
- Grant-in-aid for Scientific Research on Priority Areas
- CREST Research Project, JST
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- ANRblanc Episperm & Empreinte, INCa, and ARC-ARECA research programs
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To visualize histone acetylation in living cells, we developed a genetically encoded fluorescent resonance energy transfer ( FRET)based indicator. Response of the indicator reflects changes in the acetylation state of both K5 and K8 in histone H4. Using this acetylation indicator, we were able to monitor the dynamic fluctuation of histone H4 acetylation levels during mitosis, as well as acetylation changes in response to structurally distinct histone deacetylase inhibitors.
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