Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 106, Issue 37, Pages 15768-15773Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0906894106
Keywords
beta cell; disease model; autoimmune; directed differentiation; endoderm
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Funding
- Harvard Stem Cell Institute (Kurtzig Fund)
- Russell Berrie Foundation
- Handler Foundation
- New York Stem Cell Foundation
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Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic beta cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.
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