Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 106, Issue 8, Pages 2549-2553Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0900008106
Keywords
biosynthesis; natural products; thiazolylpeptides
Categories
Funding
- National Institutes of Health Grants [CA24487, CA59021, GM20011, GM49338]
- Department of Molecular Biology
- Center for Computational and Integrative Biology at Massachusetts General Hospital
- Broad Institute of Massachusetts Institute of Technology and Harvard
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The thiazolylpeptides are a family of > 50 bactericidal antibiotics that block the initial steps of bacterial protein synthesis. Here, we report a biosynthetic gene cluster for thiocillin and establish that it, and by extension the whole class, is ribosomally synthesized. Remarkably, the C-terminal 14 residues of a 52-residue peptide precursor undergo 13 posttranslational modifications to give rise to thiocillin, making this antibiotic the most heavily posttranslationally-modified peptide known to date.
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