Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 106, Issue 18, Pages 7595-7600Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0811343106
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- NIMH NIH HHS [R01 MH060929, MH060929] Funding Source: Medline
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Cortical GABAergic interneurons, most of which originate in the ganglionic eminences, take distinct tangential migratory trajectories into the developing cerebral cortex. However, the ligand receptor systems that modulate the tangential migration of distinct groups of interneurons into the emerging cerebral wall remain unclear. Here, we show that netrin-1, a diffusible guidance cue expressed along the migratory routes traversed by GABAergic interneurons, interacts with alpha 3 beta 1 integrin to promote interneuronal migration. In vivo analysis of interneuron-specific alpha 3 beta 1 integrin, netrin-1-deficient mice (alpha 3(lox/-)Dlx5/6-CIE, netrin-1(-/-))reveals specific deficits in the patterns of interneuronal migration along the top of the developing cortical plate, resulting in aberrant interneuronal positioning throughout the cerebral cortex and hippocampus of conditional (alpha 3(lox/-)Dlx5/6-CIE, netrin-1(-/-) mice. These results indicate that specific guidance mechanisms, such as netrin-1-alpha 3 beta 1 integrin interactions, modulate distinct routes of interneuronal migration and the consequent positioning of groups of cortical interneurons in the developing cerebral cortex.
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