Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 106, Issue 8, Pages 2735-2740Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0811073106
Keywords
bic/miR-155; LPS; TAB2; TLR/IL-1 pathway
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Funding
- Ministere de la Recherche et de la Technologie
- Reseau National Genopole
- La Ligue Nationale Contre le Cancer and the Human Frontier of Science Program
- Swiss National Science Foundation
- European Molecular Biology Organization Young Investigators
- DC-THERA Network of Excellence
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In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-derived dendritic cells. Among these miRNAs, miR-155 is highly up-regulated during maturation. Using LNA silencing combined to microarray technology, we have identified the Toll-like receptor/interleukin-1 (TLR/IL-1) inflammatory pathway as a general target of miR-155. We further demonstrate that miR-155 directly controls the level of TAB2, an important signal transduction molecule. Our observations suggest, therefore, that in mature human DCs, miR-155 is part of a negative feedback loop, which down-modulates inflammatory cytokine production in response to microbial stimuli.
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