Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 106, Issue 51, Pages 21894-21899Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0908383106
Keywords
auditory cortex; cortical laminae; information; spectrotemporal receptive field
Categories
Funding
- National Institutes of Health [DC02260, MH077970, K25MH068904]
- Coleman Memorial Fund
- Hearing Re-search Inc.
- Alfred P. Sloan Fellowship
- Searle Scholarship
- Ray Thomas Edwards Career Development
- McKnight Scholarship
- National Science Foundation [PHY-0822283]
- Center for Theoretical Biological Physics
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Sensory cortical anatomy has identified a canonical microcircuit underlying computations between and within layers. This feed-forward circuit processes information serially from granular to supragranular and to infragranular layers. How this substrate correlates with an auditory cortical processing hierarchy is unclear. We recorded simultaneously from all layers in cat primary auditory cortex (AI) and estimated spectrotemporal receptive fields (STRFs) and associated nonlinearities. Spike-triggered averaged STRFs revealed that temporal precision, spectrotemporal separability, and feature selectivity varied with layer according to a hierarchical processing model. STRFs from maximally informative dimension (MID) analysis confirmed hierarchical processing. Of two cooperative MIDs identified for each neuron, the first comprised the majority of stimulus information in granular layers. Second MID contributions and nonlinear cooperativity increased in supragranular and infragranular layers. The AI microcircuit provides a valid template for three independent hierarchical computation principles. Increases in processing complexity, STRF cooperativity, and nonlinearity correlate with the synaptic distance from granular layers.
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