Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 106, Issue 1, Pages 79-84Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0811468106
Keywords
nanofluidics; polymer confinement; self-assembly; DNA conformation
Categories
Funding
- Danish Research Council for Technology and Production Sciences [274-05-0375]
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We show that arrays of nanopit structures etched in a nanoslit can control the positioning and conformation of single DNA molecules in nanofluidic devices. By adjusting the spacing, organization and placement of the nanopits it is possible to immobilize DNA at predetermined regions of a device without additional chemical modification and achieve a high degree of control over local DNA conformation. DNA can be extended between two nanopits and in closely spaced arrays will self-assemble into connect-the-dots conformations consisting of locally pinned segments joined by fluctuating linkers. These results have broad implications for nanotechnology fields that require methods for the nanoscale positioning and manipulation of DNA.
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