Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 52, Pages 20701-20704Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0808988106
Keywords
biosensor; influenza; optical resonance
Categories
Funding
- Rowland Junior Fellowship
- National Science Foundation Division of Bioengineering and Environmental Systems [0522668]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0522668] Funding Source: National Science Foundation
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We report the label-free, real-time optical detection of Influenza A virus particles. Binding of single virions is observed from discrete changes in the resonance frequency/wavelength of a whisperinggallery mode excited in a microspherical cavity. We find that the magnitude of the discrete wavelength-shift signal can be sufficiently enhanced by reducing the microsphere size. A reactive sensing mechanism with inverse dependence on mode volume is confirmed in experiments with virus-sized polystyrene nanoparticles. By comparing the electromagnetic theory for this reactive effect with experiments, the size and mass (approximate to 5.2 x 10(-16) g) of a bound virion are determined directly from the optimal resonance shift.
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