Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 47, Pages 18171-18175Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0807296105
Keywords
fluorescence; adsorption; phase transition
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Funding
- U.S. Department of Energy, Division of Materials Science [DEFG02-02ER46019]
- National Science Foundation (NSF) [CTS-0120978, DMR 0605947, CBET 060978]
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The nonspecific adsorption of charged nanoparticles onto single-component phospholipid bilayers bearing phosphocholine head-groups is shown, from fluorescence and calorimetry experiments, to cause surface reconstruction at the points where nanoparticles adsorb. Nanoparticles of negative charge induce local gelation in otherwise fluid bilayers; nanoparticles of positive charge induce otherwise gelled membranes to fluidize locally. Through this mechanism, the phase state deviates from the nominal phase transition temperature by tens of degrees. This work generalizes the notions of environmentally induced surface reconstruction, prominent in metals and semiconductors. Bearing in mind that chemical composition in these single-component lipid bilayers is the same everywhere, this offers a mechanism to generate patchy functional properties in phospholipid membranes.
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