Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 26, Pages 8850-8854Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0709571105
Keywords
Escherichia coli; multiphoton lithography; nanobiotechnology; protein hydrogels; smart materials
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Funding
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0829166] Funding Source: National Science Foundation
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We report a method for creating stimuli-responsive biomaterials in which scanning nonlinear excitation is used to photocrosslink proteins at submicrometer 3D coordinates. Proteins with differing hydration properties can be combined to achieve tunable volume changes that are rapid and reversible in response to changes in chemical environment. Protein matrices having arbitrary 3D topographies and definable density gradients over micrometer dimensions provide the ability to effect rapid (<1 sec) and precise mechanical manipulations by means of changes in hydrogel size and shape, and applicability of these materials to cell biology is shown through the fabrication of responsive bacterial cages.
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