Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 15, Pages 5844-5849Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0710575105
Keywords
nanotubes; SERS nanoparticles
Categories
Funding
- NCI NIH HHS [U54 CA119367, P50 CA114747, T32 CA09695-15, T32 CA009695] Funding Source: Medline
- PHS HHS [5-RO1-EBB000312] Funding Source: Medline
Ask authors/readers for more resources
Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We describe a strategy for small-animal optical imaging based on Raman spectroscopy and Raman nanoparticles. Surf ace-enhanced Raman scattering nanoparticles and single-wall carbon nanotubes were used to demonstrate whole-body Raman imaging, nanoparticle pharmacokinetics, multiplexing, and in vivo tumor targeting, using an imaging system adapted for small-animal Raman imaging. The imaging modality reported here holds significant potential as a strategy for biomedical imaging of living subjects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available