Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 49, Pages 19498-19503Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0807461105
Keywords
hippocampus; laterality; NMDA receptor; AMPA receptor; spine
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [19300114, 18700344]
- Japan Society for Promotion of Science.
- Human Frontier Science Program (HFPS) [RGY0073/2006-C]
- Grants-in-Aid for Scientific Research [19300114, 18700344] Funding Source: KAKEN
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Left-right asymmetry of the brain has been studied mostly through psychological examination and functional imaging in primates, leaving its molecular and synaptic aspects largely unaddressed. Here, we show that hippocampal CA1 pyramidal cell synapses differ in size, shape, and glutamate receptor expression depending on the laterality of presynaptic origin. CA1 synapses receiving neuronal input from the right CA3 pyramidal cells are larger and have more perforated PSD and a GluR1 expression level twice as high as those receiving input from the left CA3. The synaptic density of GluR1 increases as the size of a synapse increases, whereas that of NR2B decreases because of the relatively constant NR2B expression in CA1 regardless of synapse size. Densities of other major glutamate receptor subunits show no correlation with synapse size, thus resulting in higher net expression in synapses having right input. Our study demonstrates universal left-right asymmetry of hippocampal synapses with a fundamental relationship between synaptic area and the expression of glutamate receptor subunits.
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