Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 22, Pages 7875-7880Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0803012105
Keywords
Ca2+ trigger; exocytosis; SNARE
Categories
Funding
- NINDS NIH HHS [R01 NS050655-05, R01 NS050655, NS50655] Funding Source: Medline
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Complexins (Cplxs) are key regulators of synaptic exocytosis, but whether they act as facilitators or inhibitors is currently being disputed controversially. We show that genetic deletion of all Cplxs expressed in the mouse brain causes a reduction in Ca2+-triggered and spontaneous neurotransmitter release at both excitatory and inhibitory synapses. Our results demonstrate that at mammalian central nervous system synapses, Cplxs facilitate neurotransmitter release and do not simply act as inhibitory clamps of the synaptic vesicle fusion machinery.
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