Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 27, Pages 9337-9342Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0801717105
Keywords
IgG; immune complexes; dendritic cells
Categories
Funding
- NIDDK NIH HHS [R01 DK057827, P30 DK040561-13, R01 DK051362, R01 DK053056, P30 DK034854, DK34854, R01 DK044319, R37 DK044319, DK51362, DK53056, P30 DK040561, DK44319] Funding Source: Medline
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The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.
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