Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 41, Pages 15660-15665Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0808606105
Keywords
functional model; NO reduction; N2O; trans mechanism
Categories
Funding
- National Institutes of Health [GM-69658]
- National Science Foundation [DMB0342807]
Ask authors/readers for more resources
A functional heme/nonheme nitric oxide reductase (NOR) model is presented. The fully reduced diiron compound reacts with two equivalents of NO leading to the formation of one equivalent of N2O and the bis-ferric product. NO binds to both heme Fe and nonheme Fe complexes forming individual ferrous nitrosyl species. The mixed-valence species with an oxidized heme and a reduced nonheme Fe-B does not show NO reduction activity. These results are consistent with a so-called trans mechanism for the reduction of NO by bacterial NOR.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
