Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 1, Pages 118-123Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0709376104
Keywords
energy landscape theory; protein folding; downhill folding; electrostatics; shielding
Categories
Funding
- NIGMS NIH HHS [R01 GM044557, 5R01 GM44557] Funding Source: Medline
Ask authors/readers for more resources
In contrast to classical chemical phenomenology, theory suggests that proteins may undergo downhill folding without an activation barrier under certain thermodynamic conditions. Recently, the BBL protein was proposed to fold by such a downhill scenario, but discrepancies between experimental results found in different groups argue against this. After briefly reviewing the major experimental studies of the BBL folding mechanism, we show that simulations of both coarse-grained and atomistic models can reconcile the seemingly conflicting observations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available