Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 7, Pages 2271-2273Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0712129105
Keywords
anisotropic magnetoresistance; microfluidics; NMR; adiabatic fast passage
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We report the detection of nuclear magnetic resonance (NMR) using an anisotropic magnetoresistive (AMR) sensor. A remote-detection arrangement was used in which protons in flowing water were prepolarized in the field of a superconducting NMR magnet, adiabatically inverted, and subsequently detected with an AMR sensor situated downstream from the magnet and the adiabatic inverter. AMR sensing is well suited for NMR detection in microfluidic lab-on-a-chip applications because the sensors are small, typically on the order of 10 mu m. An estimate of the sensitivity for an optimized system indicates that approximate to 6 x 10(13) protons in a volume of 1,000 mu m(3), prepolarized in a 10-kG magnetic field, can be detected with a signal-to-noise ratio of 3 in a 1-Hz bandwidth. This level of sensitivity is competitive with that demonstrated by microcoils in superconducting magnets and with the projected sensitivity of microfabricated atomic magnetometers.
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