Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 26, Pages 9006-9010Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0803051105
Keywords
GTF21; Williams-Beuren syndrome
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Funding
- NIDCR NIH HHS [K02 DE018412, R01 DE017205, K02 DE18412] Funding Source: Medline
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GTF21 and GTF21RD1 encode members of the TFII-I transcription factor family and are prime candidates in the Williams syndrome, a complex neurodevelopmental disorder. Our previous expression microarray studies implicated TFII-I proteins in the regulation of a number of genes critical in various aspects of cell physiology. Here, we combined bioinformatics and microarray results to identify TFII-I downstream targets in the vertebrate genome. These results were validated by chromatin immunoprecipitation and siRNA analysis. The collected evidence revealed the complexity of TFII-I- mediated processes that involve distinct regulatory networks. Altogether, these results lead to a better understanding of specific molecular events, some of which may be responsible for the Williams syndrome phenotype.
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