Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 18, Pages 6507-6513Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0708344105
Keywords
flagella; structure
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Funding
- MRC [G0400389, G0401595, G0400775] Funding Source: UKRI
- Medical Research Council [G0400775, G0400389, G0401595] Funding Source: Medline
- Wellcome Trust [077082] Funding Source: Medline
- Medical Research Council [G0400775, G0400389, G0401595] Funding Source: researchfish
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Recent work by several groups has significantly expanded our knowledge of the structure, regulation of assembly, and function of components of the extracellular portion of the type III secretion system (T3SS) of Gram-negative bacteria. This perspective presents a structure-informed analysis of functional data and discusses three nonmutually exclusive models of how a key aspect of T3SS biology, the sensing of host cells, may be performed.
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